Kyle Manzardo and the Guardians lost to Ian Hamilton and the New York Yankees 4-1, and the Yankees advance to their first World Series since 2009. The series was closer than the final score shows, as both teams battled to win the American League.
 
Manzardo played nine of the ten games the Guardians played in the postseason. He went 6 for 19 with two runs scored and two RBIs. This included a two-run home run in Game 3 of the ALCS, in which he also got another hit, going two for three. Manzardo also recorded a double in game 4 of the ALCS and a single in game 5. This was Manzardo's first playoff run and will look to add more to his resume in the coming years.
 
Hamilton saw action in game 3 of the ALCS before being replaced due to an injury. His status is unknown for the remainder of the postseason. The Yankees will open play in Los Angeles for game 1 of the World Series, Friday, October 25.